DESPITE , IN SPITE OF, IN DESPITE OF

A pesar de. Son intercambiables: “Despite his problems, he came. In spite of his problems, he came. Despite his illness, he went to work. In spite of his illness he went to work.”

Si sigue una clausula, tenemos que poner “the fact that: He was not paid despite the fact that he had worked very hard.”

In despite of también es aceptable: "He was happy in despite of his poverty.”